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The men were randomised to Weight Watchers weight loss programme plus placebo versus the same weight loss programme plus testosterone. During 3 months, participants randomly assigned to Weight Watchers and testosterone (mean: 6.7 +/- 0.5 kg) lost significantly more weight (20.4 +/- 3.6 vs. 12.0 +/- 1.7 kg, P < 0.0001). No significant differences were seen for body composition or serum lipid profile. In an online, open-access article published in 2016, Koopmans described several previous studies showing that testosterone improves metabolism in a number of different animal models. He also observed that the benefits can be independent of the degree of dietary restriction of the subjects involved and that the changes are specific to a single protein (leucine), or an amino acid mixture (carnitine), or the composition of particular types of food (chow or starch). "This is the first time we have reported that weight loss (and body composition and serum cholesterol) may be different due to the amount of dietary fat used", Koopmans commented. And while this finding is not unexpected, he said, it provides the first indication of "how well different macronutrients affect fat loss, although we need further evidence." "More research is needed to evaluate the effects of a single macronutrient on long-term weight loss and body composition, and it is possible that any of these macronutrients is more effective than others". To the author's knowledge, no other studies to date have reported effects of dietary fat on weight loss or weight loss maintenance in overweight women taking testosterone replacement therapy. There is however an obvious limitation to the study, Koopmans noted. "Our study is limited by the lack of the complete information on women's menstrual cycles. Furthermore, because women were recruited from two separate sites with two different dietary requirements - a diet which includes a lot of whole grains and low in protein (including meat at the time of recruitment) and a diet which is deficient in saturated fat (but rich in unsaturated fats such as nuts, which are associated with improved satiety and weight loss)." Nevertheless, he concluded, "These data support the use of testosterone to improve long-term weight loss in overweight female patients. We need further research, including data on the menstrual cycle, to evaluate the effects of long-term weight loss on the hormonal effects of dietary fat." Similar articles: